ELDERBERRY: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

Overview

Elderberry (Sambucus nigra) is the dark purple berry from the European elder tree. It has a long history of use for cold and flu.

Elderberry is a popular ingredient in supplements. It might affect the immune system, and also seems to have activity against viruses, including the flu.

Elderberry is commonly used for the common cold, flu, high cholesterol, and many other conditions, but there is no good scientific evidence to support most of these uses, with the possible exception of the flu. There is also no good evidence to support using elderberry for COVID-19.

Don't confuse elderberry with American Elder, Elderflower, or Dwarf Elder. These aren't the same and have different effects.

Uses & Effectiveness ?

Possibly Effective for

  • Flu (influenza). Taking a specific elderberry extract syrup (Sambucol, Nature's Way) seems to reduce flu symptoms when taken within 48 hours of the first symptoms. But it might not be helpful in some people, including those with lung conditions or children under 12 years of age.

There is interest in using elderberry for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Elderberry is commonly consumed in foods. Elderberry extract is possibly safe when taken for up to 12 weeks. There isn't enough reliable information to know if it is safe to use for longer than 12 weeks.

It is possibly unsafe to consume elder leaves or stems, or unripe or uncooked elderberries. Cooked elderberry seems to be safe, but raw and unripe fruit might cause nausea, vomiting, or severe diarrhea.

Special Precautions and Warnings

When taken by mouth: Elderberry is commonly consumed in foods. Elderberry extract is possibly safe when taken for up to 12 weeks. There isn't enough reliable information to know if it is safe to use for longer than 12 weeks.

It is possibly unsafe to consume elder leaves or stems, or unripe or uncooked elderberries. Cooked elderberry seems to be safe, but raw and unripe fruit might cause nausea, vomiting, or severe diarrhea. Children: Elderberry extract is possibly safe in children 5 years of age or older when taken by mouth for up to 3 days. There isn't enough reliable information to know if it is safe for children younger than 5 years of age to take elderberry. Unripe or uncooked elderberries are possibly unsafe. Don't give them to children.

Pregnancy and breast-feeding: There isn't enough reliable information to know if elderberry extract is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

"Autoimmune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Elderberry might cause the immune system to become more active. This could increase the symptoms of autoimmune diseases. If you have one of these conditions, it's best to avoid using elderberry.

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Medications that decrease the immune system (Immunosuppressants) interacts with ELDERBERRY

    Elderberry can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking elderberry along with these medications might decrease the effects of these medications.

Dosing

Elderberry fruit extracts have most often been used by adults in doses up to 1200 mg by mouth daily for 2 weeks. Elderberry is available in many different types of products, including syrups and mouth rinses. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

Don't consume green, unripe, uncooked elderberries. They contain toxins and can be poisonous.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circ*mstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

ELDERBERRY: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

FAQs

What are the precautions for elderberries? ›

DO NOT use unripe or uncooked elderberries. They may be poisonous. Elderberry appears to have few side effects when used properly for short periods of time (up to 5 days). Pregnant and breastfeeding women should not take elderberry.

What are the negative side effects of elderberry? ›

The common side effects of taking raw elderberry plant products, such as fruit, flower, leaves, bark, or root include:
  • Stomach problems.
  • Nausea and vomiting.
  • Diarrhea and constipation.

Does elderberry have any drug interactions? ›

Elderberry has no known severe, serious, or moderate interactions with other drugs. Elderberry has mild interactions with at least 28 different drugs.

Which autoimmune diseases should avoid elderberry? ›

People who have autoimmune conditions such as multiple sclerosis (MS), rheumatoid arthritis, lupus, psoriasis, and inflammatory bowel disease should not use elderberry. Elderberry may boost the immune system, which can worsen autoimmune diseases. Many autoimmune disorders require immunosuppressant drugs.

Who should not eat elderberries? ›

If you are pregnant or breastfeeding, you shouldn't take it. Other parts of the elder tree, including the branches, twigs, leaves, roots, and seeds, are toxic. They have a type of cyanogen called glycoside. People with immune problems might have reactions to elderberry.

What are elderberries used for? ›

Elderberry (Sambucus nigra) is the dark purple berry from the European elder tree. It has a long history of use for cold and flu. Elderberry is a popular ingredient in supplements. It might affect the immune system, and also seems to have activity against viruses, including the flu.

Why is elderberry not FDA approved? ›

Like elderberry, many other herbal cold remedies are not regulated by the FDA. The few studies conducted on these supplements are not shown to reduce the length of cough and cold symptoms. They also aren't shown to prevent colds or flu.

What happens if you take elderberry everyday? ›

There is a downside to consuming too much elderberry, and that is an upset stomach. Just like with any high fiber fruit, eating too much can cause stomach pain, upset stomach, and diarrhea.

Does elderberry affect the heart? ›

Elderberry may have positive effects on some markers of heart and blood vessel health. Studies have shown elderberry juice may reduce the level of fat in the blood and decrease cholesterol. In addition, a diet high in flavonoids like anthocyanins has been found to reduce the risk of heart disease ( 17 , 22 ).

Who Cannot take elderberry? ›

People who have an allergy to elder pollen might react to elderberry supplements. If you have diabetes, multiple sclerosis, lupus, or rheumatoid arthritis, talk to your doctor before taking elderberry.

Does elderberry affect your kidneys? ›

Administration of Elderberry is standard folk medicine for difficulties relating to kidney and urine, in addition to cold and cough symptoms caused by inflammation. It also suggested that about 500 milligrams per day of elderberry extract for about 12 weeks is safe and can help with kidney and urinary problems.

Can elderberry affect blood pressure? ›

Elderberries may be beneficial for the heart, as they have been associated with positive effects on blood pressure; the anthocyanin content increases the release of nitric oxide—which helps widen the blood vessels and improves blood flow, leading to a decrease in blood pressure.

Why can't people with MS take elderberry? ›

Some supplements (e.g., Echinacea, elderberry), when used regularly, may actually worsen MS by overstimulating the immune system. Some supplements may interfere with medications or medical conditions and may not be safe to use.

Does elderberry cause pancreatitis? ›

Some case reports of more severe adverse effects associated with elderberry, including acute pancreatitis, also exist. Unripe elderberries, as well as the stems and leaves of the elder tree, contain cyanide-producing compounds that can be toxic if ingested.

What does elderberry do to the liver? ›

Long-Term Supplementation of Black Elderberries Promotes Hyperlipidemia, but Reduces Liver Inflammation and Improves HDL Function and Atherosclerotic Plaque Stability in Apolipoprotein E-Knockout Mice.

How do you remove toxins from elderberries? ›

To neutralize toxins, specifically cyanide-inducing glycosides, heat treatment is a must. Boiling elderberries for at least 30 minutes is the go-to method. This ensures the destruction of harmful compounds.

How to safely prepare elderberries? ›

While I have eaten raw elderberries in small amounts with no ill effects, some people are more sensitive, so it is safer to cook them. Cooking the berries in water for at least 30 minutes deactivates the toxins. Therefore syrups and decoctions are the best way to get the benefits safely from the berries.

How to safely eat elderberries? ›

Elderberries should always be cooked and processed before they're consumed. Unripened, raw elderberries can release toxins into your body. Even ripe berries can contain trace amounts of cyanide, so you must cook elderberries before consumption.

How to remove cyanide from elderberries? ›

Simmer it for about 20 minutes; this should be enough to break down the cyanogenic compounds. But remember, you need to stir them occasionally to ensure even heat distribution. After cooking, strain the mixture using a fine-mesh sieve.

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